Об этом документе

ליקוטי שמואל — Yisro 5786

Выпуск: ליקוטי שמואל — Yisro 5786. Темы: family_education, health_mind, parsha_commentary. Поисковые термины: воспитание, дети, семья, chinuch, family, חינוך, ילדים, משפחה, здоровье, психология, стресс, health, mental, בריאות, נפש, недельная глава, парша, parsha, פרשה, פרשת השבוע. Fatima Cody Stanford, who practices obesity medicine at Massachusetts General Hospital and teaches at Harvard Medical School, said about 70 percent of patients at her practice lost coverage for GLP-1 drugs starting this year as a result of insurers pulling back. “This sounds almost like a cure, and we’ve never seen that to date.” Fractyl’s gene therapy, Rejuva, involves injecting a small dose into the pancreas with a proprietary catheter, deploying an innocuous virus to instruct insulin-making cells to produce more of the GLP-1 hormone. Lei Cao, a professor at Ohio State University who has worked on gene therapies for obesity, said that Fractyl’s harnessing of the pancreatic cells “is their strength.” She does, however, worry about the long-term effects of producing high levels of GLP-1 in the pancreas, where the hormone isn’t primarily made, such as the potential for cancer. There’s no perfect formula for calculating the optimal dose of a gene therapy, leaving Fractyl to extrapolate based on their animal studies and start with the low end of the range they expect to have a benefit, said Mark Kay, a gene therapy expert at Stanford University and a member of Fractyl’s scientific advisory board. Fractyl said that it is not relying on an “antidote” to develop its therapy, but that drugs that dial down GLP-1, if approved by regulators, “could provide an additional, external safety mechanism.” Another question is whether health plans — many of which have balked at the high cost of GLP-1 medications — would be any more willing to pay for a gene therapy with an even higher up-front cost. Though some studies show that GLP-1 medications can save health costs in the future by helping patients avoid more serious medical conditions, those benefits are often only realized after many years, while the costs have to be borne in the present. By programming the pancreatic cells to boost GLP-1, the hormone circulating throughout the entire body doesn’t surge as it does when taking GLP-1 drugs, which Fractyl says could reduce side effects linked to high concentrations in the blood. Fractyl pointed to

Издание

ליקוטי שמואל

Дата

6 февраля 2026 г.

Страниц

6

Темы: family_education, health_mind, parsha_commentary