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ליקוטי שמואל — Shemini 5784

Выпуск: ליקוטי שמואל — Shemini 5784. Темы: health_mind. Поисковые термины: здоровье, психология, стресс, health, mental, בריאות, נפש. Eisikovits Eisikovits1@gmail.com 2 Workout in a pill: Scientists move one step closer to an exercise-mimicking drug By Nicoletta Lanese Scientists are in the early days of creating a drug that can mimic cellular benefits of exercise for people unable to engage in physical activity. These switches help maintain and regenerate muscle mass and boost the activity of cells' power houses, for example, said principal investigator Bahaa Elgendy, an associate professor of medicinal chemistry and anesthesiology at Washington University School of Medicine in St. In a video interview, Elgendy added that the medicines would also be useful for those too busy to get enough exercise or who are "lazy, like myself." In previous research, Elgendy and colleagues found a molecule that turns on these exercise switches in cells in lab dishes and in animals. Being able to trigger these cellular changes without exercise would be useful for older people, people with muscle-wasting disorders and those who might lose muscle mass while taking weight-loss-inducing drugs, such as Ozempic, he told Live Science. "If everything goes well, we're hoping [to start human trials] in the next couple of years." The researchers' quest began with looking for molecules capable of plugging into structures on cells known as "estrogen-related receptors" (ERRs). For instance, studies of mice's skeletal muscle suggest activating the receptors helps boost the production of fuel by cells' mitochondria, increase the animals' exercise endurance and help cells switch to burning fats instead of sugars. "It's never been tested in humans." The researchers have a lot of work to do to test the molecules in animals, see how they're processed by the body and make any necessary tweaks before moving the candidate drugs into people. "We're hoping that this can help all of these cases," said Elgendy, who's also the co-founder of Pelagos Pharmaceuticals, a startup aimed at developing these exercise-mimicking drugs, or so-called exercise mimetics. In lab-dish studies, the compound boosted skeletal muscle's metabolism, and in mice, it improved the rodents' endurance for running and increased their number of fatigue-resistant muscle fibers. In their latest work, the team iterated upon SLU-PP-33

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ליקוטי שמואל

Дата

5 апреля 2024 г.

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4

Темы: health_mind